| 发明名称 |
METHOD FOR ANTIGEN-SPECIFIC IMMUNOREGULATION BY T-CELL ALPHA CHAIN |
| 摘要 |
Methods for modulating immune responses in an antigen-specific fashion are disclosed. The methods utilize soluble TCR.alpha. chains which are capable of binding to the antigen, and which, in the presence of an accessory component, suppress the immune response in an antigen-specific manner. The use of TCR.alpha. chains which demonstrate such activity in therapeutic protocols for treating hyperimmune and immunodeficient conditions is described.
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| 申请公布号 |
CA2179018(A1) |
申请公布日期 |
1995.06.22 |
| 申请号 |
CA19942179018 |
申请日期 |
1994.12.13 |
| 申请人 |
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY;KIRIN BEER KABUSHIKI KAISHA |
发明人 |
GREEN, DOUGLAS;FOTEDAR, ARUN;BISSONNETTE, REID;MIKAYAMA, TOSHIFUMI;ISHII, YASUYUKI |
| 分类号 |
G01N33/53;A61K38/00;A61P37/08;C07H21/04;C07K7/00;C07K14/705;C07K14/725;C07K19/00;C12N1/21;C12N15/09;C12P21/02;C12R1/19;C12R1/38;C12R1/445;(IPC1-7):C12N15/62;C12N5/10;A61K39/39;A61K39/395;G01N33/566;A61K31/70 |
主分类号 |
G01N33/53 |
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