| 摘要 |
<p>Local anesthesia of human or animal skin may be achieved with a topical solution of about 10 to 30 percent (w/v) lidocaine base dissolved in dimethyl sulfoxide (DMSO) solution. Preferably, the DMSO vehicle is a 60 to 90 (v/v) solution of DMSO in a dermatologically-acceptable solvent, such as ethanol. With a dosage of about 0.5 to 5 mg/cm2 of skin to be anesthetized, acceptable anesthesia is achieved in about 15 to 30 minutes on human facial skin and in about 1 to 2 hours on skin of the trunk or extremities. The topical anesthetic is particularly useful in minor surgical procedures on the skin, such as treatment of vascular malformations, for example by pulsed dye laser treatment.</p> |
