发明名称 |
Recombinant DNA with interferon-alpha promoter. |
摘要 |
<p>Insertion of IFN-alpha promoters in recombinant DNAs improves their expression efficiencies for useful polypeptides. Expression of such a recombinant DNA in host cells of mammalian origin is artificially controllable by the presence and absence of external stimuli using IFN-alpha inducers. Thus transformants with such a recombiant DNA readily increase to a maximized cell density with causing neither damages nor extinction due to polypeptides they produce, and subsequent exposure to IFN-alpha inducers allows the proliferated cells to efficiently produce polypeptides with significant glycosylations.</p> |
申请公布号 |
EP0658627(A2) |
申请公布日期 |
1995.06.21 |
申请号 |
EP19940309279 |
申请日期 |
1994.12.13 |
申请人 |
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO |
发明人 |
MORI, TETSUYA, 413 ABITASHION-GURANDOU-BIRU 1-12;YAMAMOTO, KOZO;OHTA, TSUNETAKA |
分类号 |
C12N15/09;C07K14/505;C07K14/56;C12N5/10;C12N15/85;(IPC1-7):C12N15/85;C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|