| 摘要 |
The invention comprises compounds of the general formula <FORM:0976105/C1/1> (wherein R1 and R2 represent hydrogen atoms or C1- 4 alkyl radicals) and non-toxic acid addition salts thereof, and their preparation by (a) reacting a compound of the formula <FORM:0976105/C1/2> (wherein X represents a halogen atom), or an acid addition salt thereof, with a water-soluble inorganic disulphide, (b) reacting a compound of the formula <FORM:0976105/C1/3> (wherein R represents an alkyl or alkoxy radical, each containing not more than 5 carbon atoms, or NH2, and Y represents an oxygen atom when R is an alkyl radical and a sulphur atom when R is an alkoxy radical or NH2) with ammonia or an alkali or alkaline earth metal hydroxide, or (c) reacting a compound of the formula <FORM:0976105/C1/4> with a mild oxidizing agent, optionally followed in each case by acid addition salt formation. The starting materials for process (a) are obtained from pyridoxamine or a C1- 4 alkyl pyridoxamine, and may be converted into the starting materials for processes (b) and (c) by standard methods. The compounds of the invention are analgesics and may be administered in the form of pharmaceutical preparations (e.g. tablets, dragees, suppositories, injection solutions and suspensions). |
