| 摘要 |
PCT No. PCT/US92/02231 Sec. 371 Date Sep. 23, 1993 Sec. 102(e) Date Sep. 23, 1993 PCT Filed Mar. 25, 1992 PCT Pub. No. WO92/17433 PCT Pub. Date Oct. 15, 1992.A process for preparing an hydroxyketone of the formula (X): <IMAGE> (X) wherein Ar represents substituted phenyl, aromatic heterocyclic, or substituted aromatic heterocyclic; R1 and R2 independently represents hydrogen, C-1 to C-16 alkyl, aromatic, substituted aromatic, aromatic heterocyclic, substituted aromatic heterocyclic or C-1 to C-5 alkyl covalently bonded to Ar, with the provision that R1 and R2 are different. The process comprises contacting a compound of the formula (V): al hydroxylating agent at a temperature of about -85 DEG C. or less. Compounds of the formulae <IMAGE> also are disclosed.
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