发明名称 |
Binding structures directed against the ca55.1 antigen |
摘要 |
Antibodies which recognize a tumor related antigen designated CA55.1 such as hybridoma 55.1 deposited as ECACC deposit no. 93081901 in which the complementarity determining regions have the following sequences: a) heavy chain CDR1 G Y W I H (SEQ ID NO: 27) CDR2 E V N P S T G R S D Y N E K F K N (SEQ ID NO: 28) CDR3 E R A Y G Y D D A M D Y (SEQ ID NO: 29) b) light chain CDR1 K S S Q S L L N S R T R K N Y L A (SEQ ID NO: 30) CDR2 W A S T R T S (SEQ ID NO: 31) CDR3 K Q S Y T L R T (SEQ ID NO: 32) or a conservative analogue thereof. The peptide ACEHRGSGWC (SEQ ID NO: 26), as displayed on the surface of bacteriophage NCIMB No. 40638, is a mimic of the tumor related antigen CA55.1. |
申请公布号 |
AU1113095(A) |
申请公布日期 |
1995.06.19 |
申请号 |
AU19950011130 |
申请日期 |
1994.11.29 |
申请人 |
ZENECA LIMITED |
发明人 |
MICHAEL SAMUEL ROSE;CHRISTOPHER BOOT;CLIVE GRAHAM COPLEY;DOUGLAS STEPHEN PATERSON;SUSAN MARGARET HALL;ANDREW FIRMIN WRIGHT;DAVID CHARLES BLAKEY |
分类号 |
A01H5/00;A01K67/027;A61K38/00;A61K39/00;A61K39/38;A61K39/395;A61P35/00;C07K7/06;C07K7/08;C07K14/705;C07K16/30;C12N5/10;C12N7/00;C12N15/09;C12N15/13;C12P21/08;G01N33/53;G01N33/577 |
主分类号 |
A01H5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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