AMINO ACID SALTS OF AND METHODS FOR PREPARING ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS

摘要

Compounds of the formula I <IMG> wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R7 is an amino acid such as arginine or lysine; and tet is <IMG> or <IMG> , where R8 is hydrogen, C1-4 alkyl, C1-4 alkcoxyalkyl or (2-methoxy-ethoxy)methyl; methods of preparing compouds of formula II <IMG> and intermediates. The compounds of folmula I and II are inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis.