PHOSPHITE-BORANE COMPOUNDS, AND METHOD OF MAKING THE SAME.

摘要

Nucleosidyl phosphite-borane compounds of the formula: wherein: Nucleoside is a natural or synthetic nucleoside connected to the phosphorus atom via a hydroxyl oxygen; each X is independently selected from O and BHR3R4;R1 is selected from H, alkyl, aryl, alkyaryl, monovalent metal ions, and ammonium cation; R2 is selected from OR1 and N(R5)2, wherein R5 is independently selected from H, C1-C10 linear or branched alkyl or aryl; R3 is selected from H, CN, COOH, carboxyl salts, COOR6 and CONHR6, wherein R6 is selected from H, C1-C10 alkyl, alkylaryl and aryl; R4 is selected from H and C1-C10 alky; and n is 1 to 2.