| 摘要 |
PURPOSE: To obtain an inexpensive inhibitor of bone resorption or cartilage degradation containing wortmannin and its analog as active ingredients and free from adverse effects. CONSTITUTION: This inhibitor contains a compound selected from a group comprising compounds of formula I (R is H or acetoxy; R' is a 1-6C alkyl), formula II, formula III (R" is H, a 1-6C alkyl or C(O)OR"'; R"' is H or a 1-6C alkyl), formula IV (R<1> is H, methyl or ethyl; R<2> is H or methyl) or its salt as an active ingredient. The compound is obtained by culturing A 24603.1 strain and isolating and purifying the cultured product. Bone resorption proceeds by operation of osteoclast (same as chondroclast) and osteoclast has abilities to resorb both of hydroxyapatite inorganic material and organic matrix of bone. The inhibitor is useful for bone loss-related diseases such as osteoporosis after menopause and daily dose of the inhibitor is 0.001-10 mg/kg. |
