摘要 |
PCT No. PCT/EP89/00682 Sec. 371 Date Feb. 24, 1994 Sec. 102(e) Date Feb. 24, 1994 PCT Filed Jun. 16, 1989 PCT Pub. No. WO89/12630 PCT Pub. Date Dec. 28, 1989.Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) <IMAGE> (I) wherein X represents a -CH(R4)- group, an oxygen atom or a -S(O)n- group where n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as defined herein; and Q represents hydrogen, carboxy, C2-C7 alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts have immunomodulating activity and can be used in particular as immunomodulating agents, e.g. in the treatment of acute and chronic infections of both bacterial and viral origin, alone or in association with antibiotic agents, and in the treatment of neoplastic diseases, alone or in association with antitumoral agents, in mammals.
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