MIXED CRYSTALS OF INSULIN AND INSULIN DERIVATIVES, A PROCESS FOR THE PREPARATION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS, AND THE USE THEREOF FOR THE TREATMENT OF DIABETES MELLITUS

摘要

Mixed crystals composed of A. unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and B. at least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin (A) and Arg-B31 human insulin and/or Arg2-(B31-32) human insulin (B) are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.