Novel integrin-binding peptides

摘要

This invention is directed to novel integrin binding peptides. These peptides bind to alpha v- or alpha 5-containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RX1ETX2WX3 ÄSEQ ID NO: iÜ (especially RRETAWA ÄSEQ ID NO: 8Ü) ; RGDGX ÄSEQ ID NO: 2Ü, in which X is an amino acid with a hydrophobic, aromatic side chain; the double cyclic CX1CRGDCX2C ÄSEQ ID NO:- 15Ü; and RLD. The peptides generally exhibit their highest binding affinity when they assume a conformationally stabilized configuration. This invention also provides methods of using these peptides.