| 摘要 |
Despite the introduction of molecular methods, such as the polymerase chain reaction, and the discovery of highly polymorphic microsatellite markers, genotyping remains a rate limiting factor in our ability to localize disease genes by linkage. This invention provides a method for genotyping multiple loci by semi-automated fluorescence-based techniques that is both highly accurate and efficient as compared to conventional techniques. The semi-automated techniques developed will be useful in high resolution genomic analyses including: linkage studies, cancer genetics, forensics, and cytogenetics including studies of uniparental disomy or other patterns of chromosomal inheritance.
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