发明名称 Pyridazinamin-Derivate.
摘要 Novel pyridazinamine derivatives of formula <CHEM> wherein R<1> is hydrogen, C1-6alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C1-6alkyl)amino, cyano, C1-6alkyloxy, aryloxy, arylC1-6alkyloxy, C1-6alkylthio, arylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfinyl, aryllsulfonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl or aryl; R<2> and R<3> each independently are hydrogen or C1-6alkyl, or R<2> and R<3> combined may form a bivalent radical of formula -CH=CH-CH=CH- G is a bivalent radical of formula <CHEM> X is O, S, NR<8> or a direct bond; said R<8> being hydrogen or C-6alkyl; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-virals; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
申请公布号 DE3852816(T2) 申请公布日期 1995.06.08
申请号 DE19883852816T 申请日期 1988.11.17
申请人 JANSSEN PHARMACEUTICA N.V., BEERSE, BE 发明人 STOKBROEKX, RAYMOND A., B-2340 BEERSE, BE;VAN DER AA, MARCEL J.M., B-2460 KASTERLEE, BE;LUYCKX, MARCEL G.M., B-2440 GEEL, BE;GRAUWELS, GILBERT A.J., B-2300 KESSEL-LO, BE
分类号 A61K31/496;A61K31/50;A61K31/501;A61P31/12;C07D207/08;C07D207/16;C07D211/46;C07D237/20;C07D237/22;C07D237/24;C07D237/34;C07D263/10;C07D263/14;C07D263/32;C07D265/06;C07D265/08;C07D401/04;C07D403/04;C07D413/12;C07D413/14;C07D451/02 主分类号 A61K31/496
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