New bi:cyclic piperazinone carboxamide, carboxylic or sulphonic ester

摘要

Bicyclic piperazinone derivs. of formula (I) and their salts are new. Two of A, B, D and E are CH and the other two are CH or N; G = 1-6C alkyl, (CH2)nG', COR1 or SO2R1; n = 0-4; G' = phenyl (opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3), heteroaryl (opt. monosubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or 3-6C cycloalkyl (opt. substd. by 1-3C alkyl); R1 = H or 1-6C alkyl; M, Q = a direct bond, 1-6C n-alkylene (opt. substd. by 1-6C alkyl or Ar) or CH=CH; Ar = phenyl (opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or heteroaryl (opt. monosubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3); L, T = COOR3, CONR3R4 or SO2OR3; R3 and R4 = H, 1-6C alkyl, OR5 or SR5; R5 = 1-6C alkyl or Ar; X, Y = H, 1-6C alkyl, 1-6C alkoxy or 1-6C alkylthio, phenyl or benzyl (both opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or CONR3R4 or SO2NR3R4.