| 摘要 |
<p>PCT No. PCT/US93/01991 Sec. 371 Date Sep. 29, 1994 Sec. 102(e) Date Sep. 29, 1994 PCT Filed Mar. 5, 1993 PCT Pub. No. WO93/19749 PCT Pub. Date Oct. 14, 1993Novel compounds of Formula (I) <IMAGE> where X4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.</p> |
