| 摘要 |
PCT No. PCT/US91/03369 Sec. 371 Date Feb. 1, 1993 Sec. 102(e) Date Feb. 1, 1993 PCT Filed May 14, 1991 PCT Pub. No. WO92/01688 PCT Pub. Date Feb. 6, 1992.Quinuclidine derivatives of the formula <IMAGE> I <IMAGE> II or <IMAGE> III and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R1, R2 and R3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain and migraine.
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