| 摘要 |
PCT No. PCT/EP89/01300 Sec. 371 Date Apr. 29, 1991 Sec. 102(e) Date Apr. 29, 1991 PCT Filed Oct. 26, 1989 PCT Pub. No. WO90/05133 PCT Pub. Date May 17, 1990.Compounds of the formula <IMAGE> (I) and the pharmaceutically acceptable salts thereof, wherein: Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; R is -CN or -CONH2; and R1 is <IMAGE> where X and X1 are each independently O or CH2; and m is 1, 2 or 3, are muscarinic receptor antagonists useful in the treatment of diseases and conditions associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome.
|
