Multiphase pharmaceutical formulations

摘要

PCT No. PCT/EP91/01204 Sec. 371 Date Dec. 18, 1992 Sec. 102(e) Date Dec. 18, 1992 PCT Filed Jun. 26, 1991.The invention provides a multiphase pharmaceutical composition for combatting skin and anorectal conditions requiring medication comprising at least one phase containing one or more medicaments for combatting said disease and at least one porous phase containing a silicone oil absorbed therein and adapted for release, preferably delayed release, of the silicone oil whereby application of said composition at a region affected by said skin or anorectal condition deposits said medicament or medicaments thereon and a layer of silicone oil is formed thereover thus protecting the medicaments from erosion by aqueous media.