摘要 |
A library comprises at least six different sugar-containing molecules selected from (i) carbohydrates each derived from at least two saccharide monomers, and (ii) glycoconjugates. Such a library may comprise disaccharides or linear or branched trisaccharides. It may be prepared from a compound having at least two OH groups which are modified by independently-removable blocking groups. A novel process comprises synthesising a polysaccharide of the formula sugarn, n representing the number of mono- and/or oligo-saccharide units from which the polysaccharide may be derived, comprises the steps of coupling sugar2 with a conjugate of the formula Q-sugar1, Q being a removable lipophilic or polymeric material, in a solvent for the conjugate; adding a non-solvent for the resultant conjugate Q-sugar1-sugar2; repeating the said steps n-2 times, as necessary, selecting the sugar to be coupled independently each time; and removing Q from the resultant coupled conjugate. |
申请人 |
OXFORD GLYCOSYSTEMS LTD;CAMPION, COLIN;ALI, MEZHER, HUSSEIN;ORCHARD, MICHAEL, GLEN;COURTNEY, STEPHEN, MARTIN;PAREKH, RAJESH, BHIKHU |
发明人 |
CAMPION, COLIN;ALI, MEZHER, HUSSEIN;ORCHARD, MICHAEL, GLEN;COURTNEY, STEPHEN, MARTIN;PAREKH, RAJESH, BHIKHU |