INHIBITION OF SMOOTH MUSCLE MIGRATION AND PROLIFERATION WITH HYDROXY CARBAZOLE COMPOUNDS

摘要

The present invention provides a new medical use of the hydroxycarbazole compounds of Formula (I), preferably the hydroxylated metabolites of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) (carvedilol), for inhibiting the migration and proliferation of smooth muscle cells. In particular, the present invention provides a new use for the hydroxycarbazole compounds of Formula (I) for prevention of restenosis following percutaneous transluminal coronary angioplasty (PTCA), suppression of the progression of vascular hypertrophy associated with hypertension, and prevention of development of atherosclerosis. In formula (I) R1-R9 are independently -H or -OH, with the proviso that at least one of R1-R9 is OH.