发明名称 Verfahren zur Herstellung von am Ring hydroxyliertem alpha-Methylphenylalanin
摘要 Compounds of formula <FORM:1118665/C2/1> wherein n is 0 or 1, R1 and R2 are H, C1- 5 alkyl, C1- 6 alkanoyl, or alkoxyalkyl, or together form CH2, Z is CH2 or CO and X is -C(CH3)(NO2) -CO2R3 (R3 = C1- 5 alkyl), are prepared by reacting the halide of the above formula (X = Br or Cl) with HC(CH3)(NO2)CO2R3. The products may be reduced to corresponding amino-esters of said formula, wherein Z is CH2 or CHOH, and X is -C(CH3)(NH2)CO2R3.
申请公布号 DE1543778(A1) 申请公布日期 1969.12.18
申请号 DE19661543778 申请日期 1966.10.20
申请人 MERCK & CO.,INC. 发明人 FREDERICK HINKLEY,DAVID
分类号 C07C205/53;C07D317/60 主分类号 C07C205/53
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