ESTERS OF SUBSTITUTED-HYDROXYACETYL PIPERAZINE PHENYL OXAZOLIDINONES

摘要

A compound of structural Formula (I) or pharmaceutically acceptable salts thereof wherein: R is -C(O)-R<1>, -PO3= or -P(O)(OH)2; R<1> is C1-6 alkyl, -N(R<4>)2, C1-6 alkyl-N(R<4>)2, -phenyl-N(R<4>)2, -phenyl-NHC(O)CH2NH2, -C2H4-morpholinyl, pyridinyl, C1-6 alkyl-OH, C1-6 alkyl-OCH3, C1-6 alkyl C(O)CH3, -O-C1-6 alkyl-OCH3, C0-3 alkyl-piperazinyl (optionally substituted with C1-3 alkyl), imidazolyl, C1-6 alkyl-COOH, -C(CH2OH)2CH3; R<2> and R<3> are independently selected from hydrogen or F except at least one of R<2> or R<3> is F; R<4> are independently selected from hydrogen or C1-6 alkyl. The compounds are water soluble and are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including multiply-resistant staphylococci, enterococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis.