发明名称 |
Immunostimulatory imidazole derivatives, their preparation and their pharmaceutical compositions. |
摘要 |
<p>The invention provides imidazole derivatives represented by the formula: …<CHEM>… (or the corresponding keto form) wherein Y is a hydroxy group, a lower alkoxy group or an amino group, and their pharmaceutically acceptable salts. These compounds have a potent immunostimulating activity and are useful for the prevention and immunostimulatory therapy of various diseases. The compounds where Y is alkoxy of 1 to 4 carbon atoms or amino may be prepared by reacting aminomalonamide with an imide ester …<CHEM>… or a salt thereof or with an orthoester… (R3O)3CCH2COY… where R2 is an imido ester moiety and R3 is alkyl, and the product compounds where Y is lower alkoxy can be hydrolysed to give the corresponding compound where Y is hydroxy.</p> |
申请公布号 |
EP0003265(A1) |
申请公布日期 |
1979.08.08 |
申请号 |
EP19780300921 |
申请日期 |
1978.12.29 |
申请人 |
SUMITOMO CHEMICAL COMPANY LIMITED |
发明人 |
ATSUMI, TOSHIO;TARUMI, YUZO;KIYOHARA, TAKAO |
分类号 |
A61K31/415;A61P37/04;C07D233/90;(IPC1-7):07D233/90;61K31/415 |
主分类号 |
A61K31/415 |
代理机构 |
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地址 |
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