BLOOD COAGULATION RETARDANTS AND DEVICES

摘要

The invention provides methods of using anticoagulants to retard the coagulation of blood, so that properties and functions of blood, plasma, and blood cells may be determined analytically. The methods do not interfere with electrochemichal techniques use to detect divalent cations and permit accurate analysis of many analytes within a single blood sample, which currently require separately anticoagulated blood samples. The serine protease inhibitors used may be combined with each other or blood cell activation, aggregation, and adhesion inhibitors in mixtures that provide anticoagulant activity. The methods permit, for the first time, the possibility of using a single blood sample to perform a full range of blood, plasma, and blood cell analyses.