| 摘要 |
The invention relates to DNA encoding Borrelia burgdorferi sensu stricto outer surface protein C. Purified and recombinant forms of a 23 kDa protein from a Connecticut isolate of B. burgdorferi are described. The 23kDa protein, referred to as p23 or OspC, can be used for immunodiagnostic assays for detection of early lyme disease. The protein, amino acid coding for the protein and DNA sequences can be used to prevent Lyme disease, to diagnose/detect B.Burgdorferi in human or animal tissues or body fluids. Antibodies specific for the protein can also be generated.
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