发明名称 |
Process for preparing AZT and derivatives thereof |
摘要 |
Disclosed is a process for producing AZT (3'-azido-3'-deoxythymidine) and derivatives thereof. The process makes use of a reduction step wherein a 2'-halo-5'-protected pyrimidinyl 2'-deoxyribonucleoside compound is reduced in an ether, ester, or ketone solvent. Also, the process makes use of a displacement step wherein a 3' alpha -sulfonyl group is displaced with an azido group in the presence of a lithium salt and a base. |
申请公布号 |
AU7880594(A) |
申请公布日期 |
1995.06.01 |
申请号 |
AU19940078805 |
申请日期 |
1994.11.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BANG CHI CHEN;SANDRA L. QUINLAN |
分类号 |
C07H19/073;C07D405/04;C07H19/06 |
主分类号 |
C07H19/073 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|