| 摘要 |
<p>The invention provides a mutated glycosylated polypeptide which includes at least a part of the hIgE-Fc chain of sufficient length to bind to Fc⊂RI and/or Fc⊂RII receptor sites on human cells wherein Cys 225 has been mutated by replacement with another amino acid residue or has been deleted, optionally together with Val 224 and Ser 226 or with Val 224 Ser 226 and Arg 227, and wherein at least one of the sites Asn 394 and, if present, Asn 265 and/or Asn 371 bears a glycoside chain.</p> |
