| 摘要 |
1,179,108. Dibenzothiazopines. SCIENCE UNION ET CIE, SOC. FRANCAISE DE RECHERCHE MEDICALE. 15 Dec., 1967 [19 Dec., 1966], No. 56720/66. Heading C2C. Novel compounds (I) in which A and B are H, halo, C 1-5 alkyl, or C 1-5 alkoxy; R is C 1-5 alkyl and Y is (a) piperazino whose 4-position may be substituted by C 1-5 alkyl or hydroxyalkyl, pyrimidyl, aralkyl or substituted aralkyl or (b) -Z-(CH 2 ) n - NR 2 (R 2 ) wherein Z is O or S, n is 2, 3, 4 or 5, and R 2 is C 1-3 alkyl or -NR 2 (R 2 ) is hexamethyleneimino, piperidino or pyrrolidino, are prepared by reacting the corresponding 5-chloro compound with the appropriate piperazine derivative or Na-Z-(CH 2 ) n -NR 2 (R 2 ) in an anhydrous organic solvent at 20-100‹ C. Pharmaceutical compositions comprise a compound (I) or a pharmaceutically acceptable salt thereof in conjunction with a carrier or diluent, are administered orally, rectally or parenterally and are useful in the treatment of hypertension, brochospasms and hydroelectrolytic retention.
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