| 摘要 |
1,179,474. 6#,7# - Methylene - 9#,10αdec - steroids. T. D. THREADGOLD (Philips' Gloeilampenfabrieken N.V.). 2 Feb., 1967, No. 5028/67. Heading C2U. Novel compounds of formula wherein R 2 represents a single or double bond between carbon atoms 1 and 2, R 6 represents H, Cl or F and R 17 represents OH, esterified OH, COCH 3 or CH(OH)CH 3 , are prepared by reacting the corresponding 6-R 6 -#<SP>4</SP> '-compounds with dimethylsulphoxonium methylide, except for the above compounds wherein R 2 is a doublebond while R 6 is H which are obtained by dehydrogenating their 1,2-saturated analogues. Product interconversions described are (a) esterification of a 17#-hydroxy group, (b) oxidation of a 20-hydroxy group to an oxo group and (c) #<SP>1</SP>- dehydrogenation. Compounds of the above formula are described as possessing progestational, gonadotrophin-inhibiting, anti-estrogenic, anabolicandrogenic and pituitary-inhibiting activities. and may be made up with carriers or diluents into pharmaceutical compositions which may be administered orally, parenterally or rectally.
|
