| 摘要 |
<p>This invention provides a process for producing an optically active 1,2-diol derivative by optical resolution. The optically active 1,2-diol derivative of the formula (I) which is capable of utilizing as an intermediate of fungicidal optically-active azole derivatives can be produced by esterifying a 1,2-diol derivative of the formula (I) as a substrate with a carboxylic acid derivative of the formula (II) as a reagent in the presence of a lipase as a catalyst. <CHEM> wherein R<1> is C1 - C5 alkyl group, C3 - C7 cycloalkyl group or C1 - C5 haloalkyl group, R<2> is C1 - C3 alkyl group substituted by a phenyl group which may have one or two halogen atoms and/or C1 - C4 alkyl groups, C2 - C3 alkenyl group substituted by a phenyl group which may have one or two halogen atoms and/or C1 - C4 alkyl groups, or C1 - C3 alkyl group substituted by a phenoxy group which may have one or two halogen atoms and/or C1 - C4 alkyl groups, R<3> is C1 - C10 alkyl group or aryl group, and R<4> is hydrogen atom, C1 - C5 alkyl group, C2 - C4 alkenyl group or COR3.</p> |
