| 发明名称 |
HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR AND MUTEINS THEREOF |
| 摘要 |
An expression vector for the production of human granulocyte-macrophage colony stimulating factor (hGM-CSF) in a mammalian cell host is provided, the expression vector comprising in sequence: an SV40 origin of DNA replication; an SV40 early region promoter; an SR.alpha. promoter; a splice junction and a nucleotide sequence capable of encoding human granulocytemacrophage colony stimulating factor; and a polyadenylation site.
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| 申请公布号 |
CA1335717(C) |
申请公布日期 |
1995.05.30 |
| 申请号 |
CA19880572029 |
申请日期 |
1988.07.14 |
| 申请人 |
SCHERING BIOTECH CORPORATION |
发明人 |
YOKOTA, TAKASHI;LEE, FRANK D.;RENNICK, DONNA M.;ARAI, KEN-ICHI;ARAI, NAOKO |
| 分类号 |
C12N15/09;A61K38/00;A61P7/00;A61P31/00;A61P35/00;C07H21/04;C07K1/20;C07K1/22;C07K14/52;C07K14/53;C07K14/535;C12N5/00;C12N5/10;C12N15/00;C12N15/27;C12N15/70;C12N15/85;C12P21/02;C12R1/19;C12R1/865;C12R1/91;(IPC1-7):C12N15/85 |
主分类号 |
C12N15/09 |
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