发明名称 |
METHOD OF DIAGNOSING BLOOD CLOTS USING FIBRIN-BINDING PROTEINS |
摘要 |
A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.
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申请公布号 |
CA1335725(C) |
申请公布日期 |
1995.05.30 |
申请号 |
CA19880578453 |
申请日期 |
1988.09.26 |
申请人 |
GENENTECH, INC.;NEORX CORPORATION |
发明人 |
HADLEY, STEPHEN W.;MOHLER, MARJORIE A.;RENO, JOHN M. |
分类号 |
A61K51/08;(IPC1-7):C12N9/64;A61K49/00;C07K5/00 |
主分类号 |
A61K51/08 |
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