| 摘要 |
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic complications. The 1H-indazole-3-acetic acid derivatives have the formula: <IMG> (I) (wherein X1 and X2 are H, F, Cl, Br, CF3, alkyl or alkoxy; R is H or ester-forming group; R1 is <IMG>, <IMG>, <IMG> , <IMG> , <IMG> , <IMG> , <IMG> or <IMG> ; Y is S or O; X3 is H, F, Cl, Br, CF3, alkyl, alkoxy or <IMG> X4, X5 and X6 are H, F, Cl, Br, CF3, alkyl or alkoxy; X3 and X4, taken together with the adjacent carbon atoms, may form a benzene ring) or pharmaceutically acceptable cationic or acid addition salts thereof.
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