| 发明名称 |
Inhibitors of farnesyl-protein transferase |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting famesyl-protein transferase and the famesylation of the oncogene protein Ras.
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| 申请公布号 |
US5420334(A) |
申请公布日期 |
1995.05.30 |
| 申请号 |
US19940222773 |
申请日期 |
1994.04.04 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
SINGH, SHEO B.;BILLS, GERALD F.;LINGHAM, RUSSELL B.;MARTIN, ISABEL;SILVERMAN, KEITH C.;SMITH, JACK L. |
| 分类号 |
A61K31/12;A61K31/215;A61K31/695;C07C47/52;C07C49/747;C07C49/753;C07C49/757;C07C69/007;C07C69/013;C07F7/18;(IPC1-7):A61K31/66;A61K31/22;A61K31/44 |
主分类号 |
A61K31/12 |
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