| 摘要 |
PURPOSE:To provide an anticancer agent containing ellagitannin as an active ingredient and having a topoisomerase I-inhibiting action. CONSTITUTION:An anticancer agent contains a compound of the formula or its salt as an active ingredient. The compound of the formulas is a known compound, a kind of ellagitannin called chebulanin, and is obtained by extracting and separating a galenical KASHI (the dry fruit of terminalia chebula) and subsequently purifying the separated compound. The anticancer agent can be prepared in the form of oral or parenteral administration preparations, and is administered at a does of 1-500mg/kg/day for an adult. The galenical KASHI is the commercially available dry fruit of Terminalia chebula which is a tall tree of the Combretaceae, is used for astriction, stegnosis, hemostasis or antitussis, and contains many tannin compounds. |
