| 发明名称 |
Asymmetric synthesis of (s)-(-)-6-chloro-4-cyclopropyl-3,4-dihydro-4-Ý(2-pyridyl)eth ynyl¨-2(1h)-quinazolinone |
| 摘要 |
An asymmetric synthesis of (S)-(-)-6-chloro-4-cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone comprises the chiral addition of 2-pyridylacetylide to N1-protected 6-chloro-4-cyclopropyl-2-quinazolinone followed by removal of the protecting group. |
| 申请公布号 |
AU1048695(A) |
申请公布日期 |
1995.05.29 |
| 申请号 |
AU19950010486 |
申请日期 |
1994.11.04 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
MARK A HUFFMAN;NOBUYOSHI YASUDA;ANN E DECAMP;EDWARD J.J. GRABOWSKI |
| 分类号 |
C07D239/80;C07D401/06 |
主分类号 |
C07D239/80 |
| 代理机构 |
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