| 摘要 |
1,185,096. Antibiotic compositions. UPJOHN CO. 12 July, 1967 [31 Aug., 1966], No. 32144/67. Heading A5B. [Also in Division C3] Antimicrobial pharmaceutical compositions comprise as active ingredient novel trimethylsilyl ethers of the free base and the acid addition salt forms of the antibiotic lincomycin compounds of the formula where R 1 is H or C 1-8 alkyl, R 2 is C 3-12 alkyl, R 3 is methyl or ethyl and X is chlorine, bromine or hydroxy. In Example 16, an aqueous suspension comprises 2,3,4-tris-O-(trimethylsilyl) lincomycin and in Example 17, tetrakis- O-(trimethylsilyl) lincomycin is prepared in a vegetable, e.g. peanut oil, and is useful for intramuscular injection.
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