USE OF IGF-BP FOR REFOLDING OF IGF

摘要

The invention relates to the use of Insulin-like growth factor binding protein (IGF-BP) for refolding of Insulin-like growth factor (IGF). The binding protein is preferably any of IGF-BP-1, IGF-BP-2, IGF-BP-3, IGF-BP-4, IGF-BP-5 and IGF-BP-6 and the Insulin-like growth factor is preferably IGF-I. It also relates to the process for the production of biologically active, native IGF-I or IGF-II, characterized in that IGF-I or IGF-II in a reduced or misfolded form is subjected to treatment with IGF-BP.