PIPERIDINYL CAMPHORSULFONYL OXYTOCIN ANTAGONISTS

摘要

Spirocyclic compounds of formula (I), where m is an integer from zero to one; Y is CH or CH2; and X is C=O, CH2, PO2H, PO2Z, where Z is C1-10 alkyl, SO2, CONH, or SO2NH. Such compounds are useful as oxytocin and vasopressin receptor antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.