摘要 |
The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein R<1>, R<2> and R<10> are the same or different and independently represent alkyl, alkoxy, hydroxy, phenyl, halogen, trifluoromethyl, cyano, or hydrogen; q is 0 or 1; R<3> represents hydrogen, alkyl, alkoxy, or hydroxy; X represents O, S or (CH2)m wherein m is an integer from 0 to 4; A represents O or S(O)n wherein n is 0, 1, or 2; Alk<1> is straight or branched chain alkyl having 1 to 6 carbon atoms; p is 0 or 1; and R represents: (a) alkyl; (b) OH; (c) OR<4> wherein R<4> is alkyl of 1 to 6 carbon atoms; (d) NR<5>R<6> wherein R<5> is hydrogen or alkyl, and R<6> is hydrogen, alkyl, alkoxyalkyl, heterocyclealkyl, substituted heterocyclealkyl, cycloalkyl, substituted cycloalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, or Alk-NR<8>R<9> wherein Alk is alkyl of 1 to 10 carbon atoms and R<8> and R<9> each independently are hydrogen or alkyl; or NR<5>R<6> together form a heterocyclic ring which may optionally be substituted; or (e) (CH2)tCOOR<7> wherein t is an integer from 1 to 4 and r<7> is hydrogen or alkyl of 1 to 4 carbon atoms. The compounds are inhibitors or stimulators of superoxide generation. |