发明名称 |
Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
摘要 |
Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, said compound optionally substituted or polysubstituted, with the proviso that when said ring is polysubstituted, the substituents do not have a common point of attachment to said ring, and those compounds wherein no substituent on the heteroaryl group is a carboxy group or an ester group, and pharmaceutical compositions comprising such compounds.
|
申请公布号 |
US5418245(A) |
申请公布日期 |
1995.05.23 |
申请号 |
US19940137095 |
申请日期 |
1994.03.17 |
申请人 |
RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. |
发明人 |
SPADA, ALFRED P.;PERSONS, PAUL E. |
分类号 |
A61K31/404;A61K31/4406;C07D209/18;C07D213/57;C07D213/89;(IPC1-7):C07D213/57;A61K31/44 |
主分类号 |
A61K31/404 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|