摘要 |
<p>(A) Cmpd. (I) and salts (II) thereof (B) Cmpds. of general formula (III) where R1 = a hydrocarbon residue, pref. lower alkyl, cyclohexyl Ph, or Ph CH2. (C) Nitriles, amides, and imido-lower alkyl esters of III. (IV) III and Iv Intermediates for I and II I and II Hypolipaemics-long acting and of low toxicity. For peroral or reactal use at 50-500 mg/d. (a) Powdered p-phenylphenol (27.2g.) was dissolved in NaOEt (from 3.68g. Na) in EtOH (150ml.), followed by ethyl 2-bromoheptanoate (35g.), refluxed 7 h., evapd., dissolved in Et2O, and the Et2O washed with 0.5N NaOH until the alkali ceased to become hazy. The Et2O was then washed 3 X times 0.5N NaOH, with H2O, dried, and evapd., giving the pure ester. (b) This (10g.) was refluxed 1 h. with KOH (2.1g.) in MeOH (50 ml.), concd. to a syrup, dild. with H2O, and the clear soln. (if not clear, the insol. is extd. with Et2O), acidified with 2N-HCl, giving an oil which crystallised slowly. This was recryst. from MeOH-Aq. and from Me2CO - pet. spirit, giving I, m.p. 115-6 deg.</p> |