CATHEPSIN D IS AN AMYLOIDOGENIC PROTEASE IN ALZHEIMER'S DISEASE
摘要
Deposition of the neurotoxic beta-amyloid peptide is a pathologic process that takes place in the brains of Alzheimer's disease patients. Disclosed are methods for treating a patient with a therapeutic compound that functions by blocking the formation of beta-amyloid from the amyloid precursor protein (APP). We have identified the aspartic protease cathepsin D as a protease responsible for amyloidogenic processing of APP. Non-toxic compounds are disclosed that block both the in vitro activity of human cathepsin D, and the release of beta-amyloid by human cells. Such aspartic protease inhibitors thus have utility as therapeutics for Alzheimer's disease by blocking the pathologic accumulation of beta-amyloid.
申请公布号
WO9513084(A1)
申请公布日期
1995.05.18
申请号
WO1994US07043
申请日期
1994.06.21
申请人
MILES INC.;TAMBURINI, PAUL, PERRY;BENZ, GUENTER, HANS, HEINZ, HERBERT;HAEBICH, DIETER;DREYER, ROBERT, NORMAN;KOENIG, GERHARD
发明人
TAMBURINI, PAUL, PERRY;BENZ, GUENTER, HANS, HEINZ, HERBERT;HAEBICH, DIETER;DREYER, ROBERT, NORMAN;KOENIG, GERHARD