HETEROCYCLISCHE CHELATBILDENDE WIRKSTOFFE.

摘要

Heterocyclic chelating agents and salts thereof of formula I: (I) wherein X represents a bond, O or S, or a group CHR1 or NR3, each R1 represents H, a group OR3 or NR3R3, or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group NR3R3 or CON3R3; each R2 represents H, or an alkyl or alkoxy group optionally substituted by a hydroxyl or aloxy group; each R3 represents H, an optionally hydroxylated alkyl group or a group CH2Y; Y represents a group COZ, CON(OH)R4, POZ2 or SO2Z; Z represents a group OR4, NR4R4 or where each R11 is H, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is CHR11, NR11 or an oxygen atom; and each R4 represents H, or an optionally mono- or poly-hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group; with the provisos that where s is O then W is CHR11 and that where X represents a bond or CHR1, at least one group R1 or R2 represents other than H or an unsubstituted alkyl group. A process for preparing these agents and methods of heavy metal detoxification using these agents are alo described.