摘要 |
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have formula (I), wherein R<1> represents farnesyl, geranyl or geranyl-geranyl; Z represents C-R<2> or N; R<2> represents H, CN, the groups COOR<7>, SO3R<7>, CONR<7>R<8> and SO2NR<7>R<7>, wherein R<7> and R<8> are each independently hydrogen, alkyl, alkenyl, and the groups COOM and SO3M, wherein M is a cation; R<3>, R<4>, R<5> and R<6> are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, azido, or thiocyanato; X represents O, S, SO, SO2, NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of formula (I) wherein Z is N.
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