| 摘要 |
<p>A compound of formula (I), wherein R1 is C¿1-6? alkyl, C2-6 alkenyl, aryl, (C1-6 alkyl)aryl or C1-6 alkyl-AR?9¿ where A is O, NR9 or S(O)¿m?, where m = 0-2, and the or each R?9¿ is H, C¿1-4? alkyl, aryl or (C1-4 alkyl)aryl; R?2¿ is H or C¿1-6? alkyl; either R?4¿ is H or C¿1-6? alkyl optionally substituted by amino (NH2), arylamino, protected amino, aryl, di(C1-6 alkyl)amino, mono(C1-6 alkyl)amino, CO2H, protected carboxyl, carbamoyl, mono(C1-6 alkyl)carbamoyl or di(C1-6 alkyl)carbamoyl, and R?5¿ is H or C¿1-6? alkyl, or NR4R5 is pyrrolidino, piperidino or morpholino; R?6¿ is optionally-substituted C¿3-6? cycloalkyl, C3-6 cycloalkenyl, C1-6 alkyl, benzyl, (C1-6 alkoxy)benzyl, benzyloxybenzyl or 3-indolylmethyl; Alk is C1-6 alkyl or C2-6 alkenyl and n = 0 or 1; R?7¿ is H or R10CO where R10 is C¿1-4? alkyl, (C1-4 alkyl)aryl, C3-6 cycloalkyl, (C3-6 cycloalkyl)C1-4 alkyl, C2-6 alkenyl or (C2-6 alkenyl)aryl; and R?8¿ is H, C¿1-4? alkyl, (C1-4 alkyl)aryl or aryl; or a salt, solvate or hydrate thereof. Such compounds may be used to treat conditions associated with metalloproteinase, TNF and/or other activity.</p> |
