发明名称 |
RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES |
摘要 |
Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.
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申请公布号 |
CA2174517(A1) |
申请公布日期 |
1995.05.18 |
申请号 |
CA19942174517 |
申请日期 |
1994.11.04 |
申请人 |
GENENTECH, INC. |
发明人 |
LOWE, DAVID;CUNNINGHAM, BRIAN C.;OARE, DAVID;MCDOWELL, ROBERT S.;BURNIER, JOHN |
分类号 |
C12N15/09;A61K38/00;A61K38/04;A61P1/16;A61P3/00;A61P7/10;A61P9/00;A61P9/08;A61P13/02;A61P15/00;C07H21/04;C07K14/58;C12N15/12;C12P21/02;C12R1/19;(IPC1-7):C07K14/58;A61P13/00;A61K38/16;A61K38/22 |
主分类号 |
C12N15/09 |
代理机构 |
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