发明名称 |
5-Methyluridine process for large-scale preparation of 2',3'-didehydro-3'-deoxythymidine (d4T). |
摘要 |
An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-benzoyl-2' alpha -halo-3' alpha -alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product. |
申请公布号 |
EP0653436(A1) |
申请公布日期 |
1995.05.17 |
申请号 |
EP19940402484 |
申请日期 |
1994.11.03 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHEN, BANG-CHI;STARK, DERRON R.;BAKER, STEPHEN R.;QUINLAN, SANDRA L. |
分类号 |
C07D405/04;A61K31/505;A61K31/513;A61P31/12;A61P31/18;C07H19/06 |
主分类号 |
C07D405/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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