| 摘要 |
PCT No. PCT/JP91/01804 Sec. 371 Date Jun. 25, 1993 Sec. 102(e) Date Jun. 25, 1993 PCT Filed Dec. 27, 1991 PCT Pub. No. WO92/12148 PCT Pub. Date Jul. 23, 1992.An object of the invention is to provide compounds having a myocardial KD (Kinetic cell death)-inhibiting effect without being accompanied by a cardiodepressant effect. A 1,4-benzothiazepine derivative represented by the following Formula [I]: <IMAGE> [I] wherein each of substituent groups is defined as follows: R represents H or a C1-C3 lower alkoxy group; X represents O or H2; n represents 1 or 2; R1 represents H, a substituted phenyl group wherein the substituent group is OH or a C1-C3 lower alkoxy group, <IMAGE> a C1-C3 lower alkoxy group, <IMAGE> wherein R2 represents a C1-C3 acyl group, and ph represents a phenyl group, or a pharmaceutically acceptable salt thereof.
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